According to the current state of science, it is formed through a combination of genetic predisposition and some types of infection Multiple sclerosis (MS) is a severe syndrome. Based on the latest research, the development of an inflammatory autoimmune disease of the central nervous system requires a combination of certain infections and genetic predisposition – the latest research results show that Herpes viruses Belongs to his family Epstein-Barr virus For example, it increases the risk of developing MS by 32-fold.
According to international health statistics, this disease is most common among residents of Northern Europe, and 230 types of genetic combinations that predispose to the disease are most common among people living here. An Anglo-Danish research group has now found a convincing archaeological explanation for this mysterious phenomenon – He writes British Guardian.
Published in Nature magazine Stady The disease is caused by the genetic legacy of horse-drawn cattle herders who appeared in northern Europe about 5,000 years ago, as genetic variants that increase the risk of MS appeared at that time among residents of conquered areas. The results of comparative analysis of DNA databases representing modern and Bronze Age populations show that the genetic combinations in question were fixed after the inhabitants of the mounds buried in the pit. Yamnaya The culture known as All of this is supported by the fact that, according to the current scientific state, population movements from the Ponto-Caspian steppe east of the Black Sea began in the Early Bronze Age, leading to gene flow across vast distances and connecting the Scandinavian world. Pastoral populations with groups expanding into Siberia.
The research team can only speculate why genetic variants that have been shown to increase the risk of severe autoimmune diseases persist today. Their most likely hypothesis is that gene clusters that protect nomadic herders from infection with zoonotic pathogens may have generated the immune responses that led to MS in the environmental and lifestyle conditions of the 20th and 21st centuries.
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